Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cand_genes_99_zscore2_5	ad_gs_tier1	4.39e-01	3.23e-01	9.50e-01	4.80e-02
ad_gs_tier1	cand_genes_99_zscore2_5	7.59e-01	1.52e-01	2.09e-01	6.40e-01



Evaluating how well cand_genes_99_zscore2_5 genes are linked to ad_gs_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_genes_99_zscore2_5	ad_gs_tier1	0.63	0.93	1.44	0.53	2.45
ad_gs_tier1	cand_genes_99_zscore2_5	0.52	1.88	1.56	1.38	0.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_genes_99_zscore2_5	ad_gs_tier1	0.00	0.00	0.43	0.08	0.47
ad_gs_tier1	cand_genes_99_zscore2_5	0.01	1.31	0.68	0.68	0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cand_genes_99_zscore2_5	99	98	AC010616.1
ad_gs_tier1	31	30	MS4A