Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cand_genes_99_zscore2_5	ad_gs_tier2	9.50e-01	7.49e-01	7.24e-01	1.44e-01
ad_gs_tier2	cand_genes_99_zscore2_5	6.55e-01	5.13e-01	1.70e-03	2.30e-01



Evaluating how well cand_genes_99_zscore2_5 genes are linked to ad_gs_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_genes_99_zscore2_5	ad_gs_tier2	0.59	0.16	0.28	-0.10	2.27
ad_gs_tier2	cand_genes_99_zscore2_5	0.49	0.75	0.63	0.51	-0.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_genes_99_zscore2_5	ad_gs_tier2	0.00	-0.04	0.09	-0.28	1.70
ad_gs_tier2	cand_genes_99_zscore2_5	0.00	-0.24	-0.31	-0.28	-0.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cand_genes_99_zscore2_5	99	98	AC010616.1
ad_gs_tier2	46	43	TNSF12;IGH;TNSF13