Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cand_99_zscore_2_5	ad_gs_tier3	6.78e-01	8.88e-01	4.95e-01	9.86e-01
ad_gs_tier3	cand_99_zscore_2_5	5.01e-01	3.10e-01	5.81e-01	2.07e-01



Evaluating how well cand_99_zscore_2_5 genes are linked to ad_gs_tier3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_99_zscore_2_5	ad_gs_tier3	0.49	-0.64	-0.82	-0.65	-0.03
ad_gs_tier3	cand_99_zscore_2_5	0.47	-0.52	-0.56	-0.54	-1.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_99_zscore_2_5	ad_gs_tier3	0.00	-0.78	-0.62	-0.67	-0.37
ad_gs_tier3	cand_99_zscore_2_5	0.00	-0.40	-0.87	-0.47	-1.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cand_99_zscore_2_5	99	98	AC010616.1
ad_gs_tier3	25	23	AC074212.3;APT8B4