Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-combsex-four	3.99e-03	2.68e-01	2.56e-01	7.88e-01
ukbpd-combsex-four Exclusive	OT-PD-50	5.61e-02	8.18e-02	2.36e-01	8.67e-06
OT-PD-50 Exclusive	ukbpd-combsex-four Exclusive	3.14e-03	2.38e-01	2.79e-01	5.99e-01
ukbpd-combsex-four Exclusive	OT-PD-50 Exclusive	2.55e-02	4.35e-02	7.11e-02	3.61e-05
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
ukbpd-combsex-four Exclusive	Overlap	7.13e-01	3.56e-01	6.93e-01	6.34e-01
Overlap	Exclusives	6.85e-06	4.68e-06	4.25e-18	1.14e-11



Evaluating how well OT-PD-50 genes are linked to ukbpd-combsex-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-combsex-four	0.49	-0.53	-1.07	0.14	-0.12
ukbpd-combsex-four Exclusive	OT-PD-50	0.70	0.48	1.76	0.47	4.72
OT-PD-50 Exclusive	ukbpd-combsex-four Exclusive	0.48	-0.96	-0.93	-0.09	-0.34
ukbpd-combsex-four Exclusive	OT-PD-50 Exclusive	0.70	0.59	2.02	0.66	4.16
OT-PD-50 Exclusive	Overlap	0.99	2.65	1.28	1.33	1.46
ukbpd-combsex-four Exclusive	Overlap	0.78	0.49	0.96	0.50	0.77
Overlap	Exclusives	0.72	2.14	4.52	2.26	7.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-combsex-four	0.00	0.00	1.13	0.01	0.44
ukbpd-combsex-four Exclusive	OT-PD-50	0.00	0.38	0.79	0.31	3.05
OT-PD-50 Exclusive	ukbpd-combsex-four Exclusive	0.00	-0.20	0.20	-0.10	0.04
ukbpd-combsex-four Exclusive	OT-PD-50 Exclusive	0.00	0.44	0.88	0.66	2.09
OT-PD-50 Exclusive	Overlap	0.00	1.24	5.71	3.64	3.53
ukbpd-combsex-four Exclusive	Overlap	0.00	-0.26	0.87	-0.24	-0.18
Overlap	Exclusives	0.01	3.38	12.58	3.93	13.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-combsex-four Exclusive	35	34	KDM5D
Overlap	1	1