Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-combsex-fourptfive	4.52e-02	6.49e-01	4.25e-01	8.04e-01
ukbpd-combsex-fourptfive Exclusive	OT-PD-50	2.12e-01	3.64e-01	2.16e-02	9.32e-06
OT-PD-50 Exclusive	ukbpd-combsex-fourptfive Exclusive	3.28e-02	4.64e-01	8.00e-01	9.40e-01
ukbpd-combsex-fourptfive Exclusive	OT-PD-50 Exclusive	4.88e-01	3.26e-01	2.89e-02	1.79e-05
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
ukbpd-combsex-fourptfive Exclusive	Overlap	3.76e-01	2.97e-01	5.94e-01	3.96e-01
Overlap	Exclusives	7.57e-05	1.13e-06	2.91e-19	6.59e-13



Evaluating how well OT-PD-50 genes are linked to ukbpd-combsex-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-combsex-fourptfive	0.54	-0.11	-0.54	0.21	0.45
ukbpd-combsex-fourptfive Exclusive	OT-PD-50	0.69	0.05	1.01	0.08	4.19
OT-PD-50 Exclusive	ukbpd-combsex-fourptfive Exclusive	0.52	-0.55	-0.92	-0.14	0.13
ukbpd-combsex-fourptfive Exclusive	OT-PD-50 Exclusive	0.69	-0.05	0.87	0.15	4.19
OT-PD-50 Exclusive	Overlap	0.99	2.20	1.31	1.37	1.60
ukbpd-combsex-fourptfive Exclusive	Overlap	0.83	1.12	1.04	0.64	1.04
Overlap	Exclusives	0.77	1.47	5.27	2.19	6.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-combsex-fourptfive	0.00	-0.05	0.85	0.52	0.20
ukbpd-combsex-fourptfive Exclusive	OT-PD-50	0.00	-0.11	0.87	-0.06	1.85
OT-PD-50 Exclusive	ukbpd-combsex-fourptfive Exclusive	0.00	-0.24	-0.27	-0.13	-0.12
ukbpd-combsex-fourptfive Exclusive	OT-PD-50 Exclusive	0.00	-0.17	0.66	0.06	2.21
OT-PD-50 Exclusive	Overlap	0.00	23.58	6.11	5.70	4.07
ukbpd-combsex-fourptfive Exclusive	Overlap	0.00	0.10	1.10	-0.14	-0.06
Overlap	Exclusives	0.01	2.81	16.48	4.47	6.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-combsex-fourptfive Exclusive	17	16	KDM5D
Overlap	1	1