Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-combsex-four	2.58e-01	7.13e-01	1.02e-02	8.82e-01
ukbpd-combsex-four Exclusive	OT-PD-Geneburden	2.13e-01	5.04e-01	5.22e-01	5.53e-02
OT-PD-Geneburden Exclusive	ukbpd-combsex-four Exclusive	4.24e-01	8.34e-01	2.88e-03	8.17e-01
ukbpd-combsex-four Exclusive	OT-PD-Geneburden Exclusive	1.87e-01	4.62e-01	4.17e-01	1.21e-01
OT-PD-Geneburden Exclusive	Overlap	5.17e-01	7.92e-01	8.72e-01	6.93e-01
ukbpd-combsex-four Exclusive	Overlap	1.92e-01	2.88e-01	3.77e-01	1.41e-01
Overlap	Exclusives	4.36e-01	7.07e-01	8.87e-04	2.17e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-combsex-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-combsex-four	0.50	-1.03	-0.35	0.37	-0.11
ukbpd-combsex-four Exclusive	OT-PD-Geneburden	0.70	2.42	1.56	1.37	2.46
OT-PD-Geneburden Exclusive	ukbpd-combsex-four Exclusive	0.49	-0.88	-0.29	0.46	-0.34
ukbpd-combsex-four Exclusive	OT-PD-Geneburden Exclusive	0.70	2.21	1.12	1.40	2.69
OT-PD-Geneburden Exclusive	Overlap	0.65	-0.81	-0.19	-0.52	0.92
ukbpd-combsex-four Exclusive	Overlap	0.76	1.02	1.11	0.58	1.20
Overlap	Exclusives	0.53	0.69	-0.02	0.78	0.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-combsex-four	0.00	-0.08	1.16	0.24	0.09
ukbpd-combsex-four Exclusive	OT-PD-Geneburden	0.00	2.28	1.09	0.76	0.34
OT-PD-Geneburden Exclusive	ukbpd-combsex-four Exclusive	0.00	0.28	1.10	0.49	0.39
ukbpd-combsex-four Exclusive	OT-PD-Geneburden Exclusive	0.00	0.77	0.81	1.65	2.97
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.34	-0.30	-0.44	-0.03
ukbpd-combsex-four Exclusive	Overlap	0.00	0.02	0.41	-0.20	-0.08
Overlap	Exclusives	0.00	0.33	0.28	0.08	0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	11	11	
ukbpd-combsex-four Exclusive	34	33	KDM5D
Overlap	2	2