Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-combsex-fourptfive	4.04e-01	3.26e-01	5.19e-01	6.64e-01
ukbpd-combsex-fourptfive Exclusive	OT-PD-Geneburden	2.45e-01	4.24e-01	4.32e-01	6.93e-02
OT-PD-Geneburden Exclusive	ukbpd-combsex-fourptfive Exclusive	4.01e-01	3.56e-01	4.83e-01	6.77e-01
ukbpd-combsex-fourptfive Exclusive	OT-PD-Geneburden Exclusive	4.74e-01	6.41e-01	4.87e-01	3.00e-01
OT-PD-Geneburden Exclusive	Overlap	7.33e-01	1.98e-02	5.35e-01	3.37e-01
ukbpd-combsex-fourptfive Exclusive	Overlap	3.96e-01	4.75e-01	3.96e-01	2.77e-01
Overlap	Exclusives	2.71e-01	9.71e-01	4.61e-05	1.56e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-combsex-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-combsex-fourptfive	0.50	-0.91	-1.20	-0.64	0.07
ukbpd-combsex-fourptfive Exclusive	OT-PD-Geneburden	0.64	1.56	0.48	0.36	1.74
OT-PD-Geneburden Exclusive	ukbpd-combsex-fourptfive Exclusive	0.48	-0.98	-1.15	-0.55	-0.26
ukbpd-combsex-fourptfive Exclusive	OT-PD-Geneburden Exclusive	0.62	1.13	0.55	0.47	1.39
OT-PD-Geneburden Exclusive	Overlap	0.84	0.55	1.08	0.57	1.32
ukbpd-combsex-fourptfive Exclusive	Overlap	0.83	0.99	0.98	1.00	1.24
Overlap	Exclusives	0.60	0.84	0.05	1.11	2.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-combsex-fourptfive	0.00	-0.33	0.67	-0.22	-0.06
ukbpd-combsex-fourptfive Exclusive	OT-PD-Geneburden	0.00	0.61	-0.22	-0.18	0.30
OT-PD-Geneburden Exclusive	ukbpd-combsex-fourptfive Exclusive	0.00	-0.35	0.28	-0.20	-0.03
ukbpd-combsex-fourptfive Exclusive	OT-PD-Geneburden Exclusive	0.00	0.15	-0.18	-0.16	-0.10
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.19	1.77	-0.19	-0.04
ukbpd-combsex-fourptfive Exclusive	Overlap	0.00	0.08	0.92	0.04	0.21
Overlap	Exclusives	0.00	1.28	0.00	-0.04	0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-combsex-fourptfive Exclusive	17	16	KDM5D
Overlap	1	1