Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-female-threeptfive	7.73e-02	8.97e-01	1.29e-01	7.85e-01
ukbpd-female-threeptfive Exclusive	OT-PD-50	5.95e-01	3.73e-01	6.59e-01	3.65e-05
OT-PD-50 Exclusive	ukbpd-female-threeptfive Exclusive	6.59e-02	9.74e-01	1.40e-01	9.36e-01
ukbpd-female-threeptfive Exclusive	OT-PD-50 Exclusive	2.91e-01	2.84e-01	6.80e-01	4.08e-05
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
ukbpd-female-threeptfive Exclusive	Overlap	7.52e-01	9.90e-01	8.51e-01	5.35e-01
Overlap	Exclusives	8.52e-05	2.23e-04	4.80e-20	1.88e-07



Evaluating how well OT-PD-50 genes are linked to ukbpd-female-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-female-threeptfive	0.52	1.42	0.41	0.91	0.52
ukbpd-female-threeptfive Exclusive	OT-PD-50	0.68	0.13	1.20	0.32	4.57
OT-PD-50 Exclusive	ukbpd-female-threeptfive Exclusive	0.51	1.19	0.19	0.57	0.29
ukbpd-female-threeptfive Exclusive	OT-PD-50 Exclusive	0.68	0.40	1.30	0.24	4.44
OT-PD-50 Exclusive	Overlap	0.99	2.27	1.23	1.66	1.64
ukbpd-female-threeptfive Exclusive	Overlap	0.70	-0.38	-0.34	-0.17	0.74
Overlap	Exclusives	0.65	1.73	3.67	1.84	5.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-female-threeptfive	0.00	0.04	0.58	0.14	0.21
ukbpd-female-threeptfive Exclusive	OT-PD-50	0.00	-0.14	0.27	0.05	2.99
OT-PD-50 Exclusive	ukbpd-female-threeptfive Exclusive	0.00	0.04	0.30	-0.27	-0.03
ukbpd-female-threeptfive Exclusive	OT-PD-50 Exclusive	0.00	0.21	0.61	-0.12	2.17
OT-PD-50 Exclusive	Overlap	0.00	25.57	5.52	7.19	1.93
ukbpd-female-threeptfive Exclusive	Overlap	0.00	-0.37	-0.55	-0.52	-0.17
Overlap	Exclusives	0.01	2.69	8.45	2.77	7.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-female-threeptfive Exclusive	69	69	
Overlap	1	1