Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-female-fourptfive	4.68e-02	5.92e-01	4.45e-01	5.12e-01
ukbpd-female-fourptfive Exclusive	OT-PD-50	8.97e-02	1.69e-01	3.95e-02	3.51e-08
OT-PD-50 Exclusive	ukbpd-female-fourptfive Exclusive	3.43e-02	3.98e-01	4.41e-01	7.23e-01
ukbpd-female-fourptfive Exclusive	OT-PD-50 Exclusive	1.47e-01	2.29e-01	1.66e-02	7.09e-08
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	7.92e-02
ukbpd-female-fourptfive Exclusive	Overlap	8.12e-01	8.32e-01	5.35e-01	5.94e-01
Overlap	Exclusives	7.83e-04	2.09e-05	3.66e-19	4.10e-11



Evaluating how well OT-PD-50 genes are linked to ukbpd-female-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-female-fourptfive	0.55	-0.23	-0.28	0.24	0.72
ukbpd-female-fourptfive Exclusive	OT-PD-50	0.71	0.38	0.64	0.38	5.71
OT-PD-50 Exclusive	ukbpd-female-fourptfive Exclusive	0.53	-0.70	-0.64	0.18	0.20
ukbpd-female-fourptfive Exclusive	OT-PD-50 Exclusive	0.71	0.32	0.63	0.52	4.98
OT-PD-50 Exclusive	Overlap	0.99	2.42	1.33	1.64	1.66
ukbpd-female-fourptfive Exclusive	Overlap	0.77	0.13	0.17	0.42	0.78
Overlap	Exclusives	0.76	1.67	5.91	1.96	7.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-female-fourptfive	0.00	-0.19	0.48	0.50	0.21
ukbpd-female-fourptfive Exclusive	OT-PD-50	0.00	-0.13	-0.11	-0.09	3.10
OT-PD-50 Exclusive	ukbpd-female-fourptfive Exclusive	0.00	-0.21	-0.25	-0.23	-0.10
ukbpd-female-fourptfive Exclusive	OT-PD-50 Exclusive	0.00	-0.12	-0.11	0.12	2.47
OT-PD-50 Exclusive	Overlap	0.00	35.25	5.48	5.96	0.83
ukbpd-female-fourptfive Exclusive	Overlap	0.00	-0.30	-0.42	-0.19	-0.13
Overlap	Exclusives	0.01	2.75	16.63	2.48	22.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-female-fourptfive Exclusive	18	18	
Overlap	1	1