Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-fourptfive	6.73e-01	7.25e-01	5.25e-02	8.14e-01
ukbpd-female-fourptfive Exclusive	OT-PD-Geneburden	5.54e-01	5.86e-01	3.55e-01	3.21e-02
OT-PD-Geneburden Exclusive	ukbpd-female-fourptfive Exclusive	5.80e-01	5.63e-01	4.43e-02	8.06e-01
ukbpd-female-fourptfive Exclusive	OT-PD-Geneburden Exclusive	7.57e-01	9.04e-01	4.83e-01	4.77e-02
OT-PD-Geneburden Exclusive	Overlap	7.52e-01	1.98e-02	3.17e-01	3.56e-01
ukbpd-female-fourptfive Exclusive	Overlap	9.50e-01	7.52e-01	7.33e-01	4.75e-01
Overlap	Exclusives	6.21e-02	7.73e-01	1.68e-05	1.11e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-female-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-fourptfive	0.54	0.26	-0.15	0.35	0.39
ukbpd-female-fourptfive Exclusive	OT-PD-Geneburden	0.65	0.44	0.78	0.67	1.59
OT-PD-Geneburden Exclusive	ukbpd-female-fourptfive Exclusive	0.52	0.18	-0.26	0.15	0.32
ukbpd-female-fourptfive Exclusive	OT-PD-Geneburden Exclusive	0.64	0.54	0.55	0.54	1.66
OT-PD-Geneburden Exclusive	Overlap	0.84	0.43	1.22	0.89	1.16
ukbpd-female-fourptfive Exclusive	Overlap	0.77	0.07	0.10	0.26	0.92
Overlap	Exclusives	0.60	1.54	0.35	1.43	1.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-fourptfive	0.00	-0.33	0.10	-0.07	0.01
ukbpd-female-fourptfive Exclusive	OT-PD-Geneburden	0.00	-0.37	-0.09	-0.28	0.08
OT-PD-Geneburden Exclusive	ukbpd-female-fourptfive Exclusive	0.00	-0.15	-0.12	-0.14	-0.10
ukbpd-female-fourptfive Exclusive	OT-PD-Geneburden Exclusive	0.00	-0.40	-0.30	-0.12	0.10
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.29	1.75	-0.01	-0.04
ukbpd-female-fourptfive Exclusive	Overlap	0.00	-0.37	-0.48	-0.26	-0.10
Overlap	Exclusives	0.00	0.93	-0.04	0.25	0.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-female-fourptfive Exclusive	18	18	
Overlap	1	1