Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-four	2.31e-01	3.28e-01	8.97e-03	9.25e-01
ukbpd-female-four Exclusive	OT-PD-Geneburden	7.27e-01	7.41e-01	8.20e-01	2.62e-01
OT-PD-Geneburden Exclusive	ukbpd-female-four Exclusive	2.54e-01	2.76e-01	1.95e-02	8.00e-01
ukbpd-female-four Exclusive	OT-PD-Geneburden Exclusive	7.48e-01	8.84e-01	7.53e-01	1.46e-01
OT-PD-Geneburden Exclusive	Overlap	7.72e-01	1.98e-02	4.95e-01	3.17e-01
ukbpd-female-four Exclusive	Overlap	5.74e-01	4.36e-01	9.31e-01	6.73e-01
Overlap	Exclusives	4.51e-02	4.89e-01	2.61e-06	4.04e-02



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-female-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-four	0.51	0.03	-0.83	-0.42	0.15
ukbpd-female-four Exclusive	OT-PD-Geneburden	0.62	-0.48	-0.07	0.20	1.44
OT-PD-Geneburden Exclusive	ukbpd-female-four Exclusive	0.50	-0.05	-0.81	-0.36	0.04
ukbpd-female-four Exclusive	OT-PD-Geneburden Exclusive	0.61	-0.36	0.26	0.06	1.33
OT-PD-Geneburden Exclusive	Overlap	0.84	0.55	1.15	0.61	1.20
ukbpd-female-four Exclusive	Overlap	0.64	-0.79	-0.81	-0.34	0.52
Overlap	Exclusives	0.58	1.64	0.75	1.28	1.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-four	0.00	0.17	0.24	-0.22	-0.06
ukbpd-female-four Exclusive	OT-PD-Geneburden	0.00	-0.49	-0.05	-0.16	0.02
OT-PD-Geneburden Exclusive	ukbpd-female-four Exclusive	0.00	0.13	0.29	0.08	0.47
ukbpd-female-four Exclusive	OT-PD-Geneburden Exclusive	0.00	-0.48	0.18	-0.17	-0.08
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.23	1.62	-0.16	0.09
ukbpd-female-four Exclusive	Overlap	0.00	-0.20	-0.90	-0.47	-0.21
Overlap	Exclusives	0.00	1.54	0.29	0.55	1.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-female-four Exclusive	31	31	
Overlap	1	1