Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-three	5.89e-02	4.24e-01	1.98e-14	3.14e-01
ukbpd-female-three Exclusive	OT-PD-Geneburden	2.39e-01	2.80e-01	2.18e-01	1.63e-01
OT-PD-Geneburden Exclusive	ukbpd-female-three Exclusive	9.11e-02	3.53e-01	4.14e-14	3.27e-01
ukbpd-female-three Exclusive	OT-PD-Geneburden Exclusive	3.65e-01	3.69e-01	2.68e-01	1.83e-01
OT-PD-Geneburden Exclusive	Overlap	7.92e-01	1.98e-02	5.54e-01	2.97e-01
ukbpd-female-three Exclusive	Overlap	7.13e-01	8.51e-01	7.33e-01	4.55e-01
Overlap	Exclusives	6.85e-04	7.64e-01	1.03e-19	4.93e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-female-three genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-three	0.49	-0.12	-0.60	-0.85	-0.47
ukbpd-female-three Exclusive	OT-PD-Geneburden	0.59	-0.91	-0.77	-0.87	1.04
OT-PD-Geneburden Exclusive	ukbpd-female-three Exclusive	0.48	-0.14	-0.62	-0.99	-0.61
ukbpd-female-three Exclusive	OT-PD-Geneburden Exclusive	0.58	-1.09	-0.76	-0.86	0.95
OT-PD-Geneburden Exclusive	Overlap	0.84	0.48	1.06	0.57	1.21
ukbpd-female-three Exclusive	Overlap	0.72	-0.25	-0.16	-0.15	0.98
Overlap	Exclusives	0.52	1.41	0.77	1.14	1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-female-three	0.01	-0.50	-0.56	-0.85	-0.63
ukbpd-female-three Exclusive	OT-PD-Geneburden	0.00	-0.58	-0.50	-0.71	-0.03
OT-PD-Geneburden Exclusive	ukbpd-female-three Exclusive	0.01	-0.51	-0.65	-0.88	-0.87
ukbpd-female-three Exclusive	OT-PD-Geneburden Exclusive	0.00	-0.55	-0.29	-0.69	0.05
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.20	1.64	-0.19	-0.02
ukbpd-female-three Exclusive	Overlap	0.00	-0.40	-0.40	-0.45	-0.06
Overlap	Exclusives	0.01	1.99	0.07	0.77	0.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-female-three Exclusive	157	154	PRAG1;SYT15;CCDC7
Overlap	1	1