Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-fourptfive	3.64e-01	9.76e-01	5.77e-01	5.27e-01
ukbpd-male-fourptfive Exclusive	OT-PD-50	2.19e-04	7.04e-05	5.81e-01	6.37e-04
OT-PD-50 Exclusive	ukbpd-male-fourptfive Exclusive	1.01e-01	8.67e-01	9.42e-01	3.47e-01
ukbpd-male-fourptfive Exclusive	OT-PD-50 Exclusive	3.36e-04	1.00e-04	6.28e-01	1.20e-03
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
ukbpd-male-fourptfive Exclusive	Overlap	1.98e-01	4.16e-01	8.71e-01	9.11e-01
Overlap	Exclusives	2.03e-04	1.01e-06	2.88e-18	3.68e-13



Evaluating how well OT-PD-50 genes are linked to ukbpd-male-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-fourptfive	0.67	0.23	0.41	1.21	1.32
ukbpd-male-fourptfive Exclusive	OT-PD-50	0.62	-1.32	-4.91	-1.34	3.04
OT-PD-50 Exclusive	ukbpd-male-fourptfive Exclusive	0.62	-0.85	-0.11	0.77	0.96
ukbpd-male-fourptfive Exclusive	OT-PD-50 Exclusive	0.62	-1.28	-4.40	-1.01	3.04
OT-PD-50 Exclusive	Overlap	0.99	2.47	1.15	1.82	1.71
ukbpd-male-fourptfive Exclusive	Overlap	0.63	-1.15	-0.78	-1.40	0.28
Overlap	Exclusives	0.80	1.47	6.44	1.73	7.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-fourptfive	0.00	3.00	0.75	1.65	0.98
ukbpd-male-fourptfive Exclusive	OT-PD-50	0.00	-0.71	-2.38	-0.88	1.08
OT-PD-50 Exclusive	ukbpd-male-fourptfive Exclusive	0.00	-0.72	-0.72	-0.10	-0.16
ukbpd-male-fourptfive Exclusive	OT-PD-50 Exclusive	0.00	-0.61	-2.43	-0.62	0.24
OT-PD-50 Exclusive	Overlap	0.00	41.16	5.24	17.02	0.67
ukbpd-male-fourptfive Exclusive	Overlap	0.00	-0.46	-0.74	-0.53	-0.23
Overlap	Exclusives	0.01	2.81	21.09	2.70	15.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-male-fourptfive Exclusive	7	6	KDM5D
Overlap	1	1