Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-four	6.91e-01	3.30e-01	1.46e-01	8.18e-02
ukbpd-male-four Exclusive	OT-PD-50	9.83e-02	1.51e-01	2.77e-04	1.10e-06
OT-PD-50 Exclusive	ukbpd-male-four Exclusive	5.40e-01	3.81e-01	1.22e-01	7.80e-02
ukbpd-male-four Exclusive	OT-PD-50 Exclusive	2.26e-02	1.19e-01	1.20e-04	4.29e-07
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
ukbpd-male-four Exclusive	Overlap	7.92e-02	4.95e-01	2.57e-01	9.50e-01
Overlap	Exclusives	8.01e-05	2.07e-05	8.75e-20	1.46e-11



Evaluating how well OT-PD-50 genes are linked to ukbpd-male-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-four	0.64	1.56	1.95	2.08	2.33
ukbpd-male-four Exclusive	OT-PD-50	0.73	0.74	1.33	0.96	6.60
OT-PD-50 Exclusive	ukbpd-male-four Exclusive	0.63	1.34	1.57	2.23	1.86
ukbpd-male-four Exclusive	OT-PD-50 Exclusive	0.74	0.99	1.55	1.17	5.59
OT-PD-50 Exclusive	Overlap	0.99	2.29	1.18	1.55	1.81
ukbpd-male-four Exclusive	Overlap	0.47	-1.50	-1.15	-1.65	-0.05
Overlap	Exclusives	0.75	1.79	5.43	1.72	7.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-four	0.00	0.20	0.74	0.53	0.96
ukbpd-male-four Exclusive	OT-PD-50	0.00	0.18	0.50	0.47	2.92
OT-PD-50 Exclusive	ukbpd-male-four Exclusive	0.00	-0.12	0.24	0.62	0.97
ukbpd-male-four Exclusive	OT-PD-50 Exclusive	0.00	0.44	0.50	0.83	4.10
OT-PD-50 Exclusive	Overlap	0.00	23.83	5.49	4.12	1.61
ukbpd-male-four Exclusive	Overlap	0.00	-0.54	-0.38	-0.41	-0.32
Overlap	Exclusives	0.01	2.76	13.56	2.85	5.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-male-four Exclusive	26	25	KDM5D
Overlap	1	1