Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-threeptfive	9.59e-03	9.97e-01	2.68e-01	8.01e-01
ukbpd-male-threeptfive Exclusive	OT-PD-50	6.52e-01	8.61e-01	6.07e-01	5.62e-05
OT-PD-50 Exclusive	ukbpd-male-threeptfive Exclusive	8.18e-03	9.79e-01	3.74e-01	9.06e-01
ukbpd-male-threeptfive Exclusive	OT-PD-50 Exclusive	3.37e-01	6.37e-01	6.97e-01	2.34e-05
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-male-threeptfive Exclusive	Overlap	2.18e-01	1.98e-01	2.57e-01	8.71e-01
Overlap	Exclusives	3.47e-04	1.86e-03	4.59e-22	2.73e-07



Evaluating how well OT-PD-50 genes are linked to ukbpd-male-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-threeptfive	0.52	0.64	0.29	0.65	0.92
ukbpd-male-threeptfive Exclusive	OT-PD-50	0.67	0.03	0.12	0.03	4.70
OT-PD-50 Exclusive	ukbpd-male-threeptfive Exclusive	0.52	0.47	0.49	0.50	0.36
ukbpd-male-threeptfive Exclusive	OT-PD-50 Exclusive	0.67	-0.14	0.44	0.05	3.76
OT-PD-50 Exclusive	Overlap	0.99	2.27	1.20	1.56	1.90
ukbpd-male-threeptfive Exclusive	Overlap	0.45	-1.43	-1.76	-1.34	-0.17
Overlap	Exclusives	0.66	1.45	4.08	1.76	6.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-threeptfive	0.00	0.84	0.03	0.37	0.36
ukbpd-male-threeptfive Exclusive	OT-PD-50	0.00	-0.26	-0.47	-0.23	2.60
OT-PD-50 Exclusive	ukbpd-male-threeptfive Exclusive	0.00	0.29	-0.00	-0.16	-0.18
ukbpd-male-threeptfive Exclusive	OT-PD-50 Exclusive	0.00	-0.40	-0.21	-0.24	0.51
OT-PD-50 Exclusive	Overlap	0.00	34.19	5.24	2.75	13.97
ukbpd-male-threeptfive Exclusive	Overlap	0.00	-0.43	-0.59	-0.61	-0.18
Overlap	Exclusives	0.01	2.17	9.09	2.80	11.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-male-threeptfive Exclusive	70	69	KDM5D
Overlap	1	1