Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-three	1.24e-04	1.72e-01	2.77e-03	1.91e-01
ukbpd-male-three Exclusive	OT-PD-50	7.42e-01	6.52e-01	7.14e-01	2.93e-05
OT-PD-50 Exclusive	ukbpd-male-three Exclusive	8.30e-05	1.90e-01	2.69e-03	1.95e-01
ukbpd-male-three Exclusive	OT-PD-50 Exclusive	6.97e-01	6.92e-01	8.74e-01	3.97e-05
OT-PD-50 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-male-three Exclusive	Overlap	7.92e-01	8.91e-01	9.31e-01	5.94e-01
Overlap	Exclusives	7.02e-06	1.92e-02	1.52e-35	2.68e-03



Evaluating how well OT-PD-50 genes are linked to ukbpd-male-three genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-three	0.53	1.27	1.43	1.59	1.18
ukbpd-male-three Exclusive	OT-PD-50	0.70	-0.20	0.40	-0.01	4.82
OT-PD-50 Exclusive	ukbpd-male-three Exclusive	0.52	1.03	1.31	1.32	1.02
ukbpd-male-three Exclusive	OT-PD-50 Exclusive	0.70	-0.16	0.49	0.04	4.45
OT-PD-50 Exclusive	Overlap	0.99	2.20	1.44	1.58	1.81
ukbpd-male-three Exclusive	Overlap	0.73	-0.14	-0.11	-0.04	0.79
Overlap	Exclusives	0.58	1.64	3.03	1.54	3.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-50 Exclusive	ukbpd-male-three	0.01	0.41	0.43	0.52	0.03
ukbpd-male-three Exclusive	OT-PD-50	0.00	-0.40	-1.89	-0.33	4.28
OT-PD-50 Exclusive	ukbpd-male-three Exclusive	0.01	0.25	0.28	0.03	-0.09
ukbpd-male-three Exclusive	OT-PD-50 Exclusive	0.00	-0.42	-1.86	-0.23	3.07
OT-PD-50 Exclusive	Overlap	0.00	4.41	6.48	4.49	12.10
ukbpd-male-three Exclusive	Overlap	0.00	-0.45	-0.34	-0.37	-0.14
Overlap	Exclusives	0.02	2.03	6.14	2.20	5.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-50 Exclusive	49	49	
ukbpd-male-three Exclusive	190	189	KDM5D
Overlap	1	1