Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-three	6.78e-02	3.06e-01	4.27e-13	3.11e-01
ukbpd-male-three Exclusive	OT-PD-Geneburden	4.57e-01	6.76e-01	7.18e-01	3.72e-02
OT-PD-Geneburden Exclusive	ukbpd-male-three Exclusive	1.07e-01	1.71e-01	1.91e-14	3.75e-01
ukbpd-male-three Exclusive	OT-PD-Geneburden Exclusive	7.76e-01	9.02e-01	8.10e-01	6.25e-02
OT-PD-Geneburden Exclusive	Overlap	6.03e-01	8.57e-01	9.89e-01	9.89e-01
ukbpd-male-three Exclusive	Overlap	8.25e-01	5.57e-01	9.08e-01	2.16e-01
Overlap	Exclusives	1.94e-01	8.33e-01	2.55e-07	7.08e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-male-three genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-three	0.52	0.06	0.83	1.02	0.94
ukbpd-male-three Exclusive	OT-PD-Geneburden	0.69	1.39	0.83	0.70	2.48
OT-PD-Geneburden Exclusive	ukbpd-male-three Exclusive	0.52	0.44	1.49	1.10	0.87
ukbpd-male-three Exclusive	OT-PD-Geneburden Exclusive	0.68	0.98	0.14	0.90	2.43
OT-PD-Geneburden Exclusive	Overlap	0.49	-1.42	-0.79	-1.09	-0.08
ukbpd-male-three Exclusive	Overlap	0.70	0.51	0.81	0.49	1.16
Overlap	Exclusives	0.52	1.58	0.66	1.19	1.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-three	0.01	0.39	1.01	0.46	0.28
ukbpd-male-three Exclusive	OT-PD-Geneburden	0.00	1.08	-0.28	-0.00	3.12
OT-PD-Geneburden Exclusive	ukbpd-male-three Exclusive	0.01	0.66	1.13	0.79	0.45
ukbpd-male-three Exclusive	OT-PD-Geneburden Exclusive	0.00	0.72	-0.27	0.34	4.38
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.44	-0.58	-0.34	-0.30
ukbpd-male-three Exclusive	Overlap	0.00	-0.28	-0.33	-0.21	-0.11
Overlap	Exclusives	0.01	0.14	0.09	0.18	0.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	10	10	
ukbpd-male-three Exclusive	188	187	KDM5D
Overlap	3	3