Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-threeptfive	1.80e-01	8.53e-01	1.03e-04	7.77e-01
ukbpd-male-threeptfive Exclusive	OT-PD-Geneburden	8.63e-01	5.95e-01	8.12e-01	4.52e-01
OT-PD-Geneburden Exclusive	ukbpd-male-threeptfive Exclusive	1.41e-01	7.04e-01	1.24e-05	7.91e-01
ukbpd-male-threeptfive Exclusive	OT-PD-Geneburden Exclusive	9.80e-01	7.76e-01	9.84e-01	2.64e-01
OT-PD-Geneburden Exclusive	Overlap	6.53e-01	1.98e-02	3.37e-01	3.96e-01
ukbpd-male-threeptfive Exclusive	Overlap	9.90e-02	1.98e-01	3.56e-01	1.00e+00
Overlap	Exclusives	7.70e-03	4.78e-01	7.30e-12	1.19e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-male-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-threeptfive	0.52	-0.63	-0.21	-0.18	0.69
ukbpd-male-threeptfive Exclusive	OT-PD-Geneburden	0.59	-0.63	-0.82	-0.73	1.11
OT-PD-Geneburden Exclusive	ukbpd-male-threeptfive Exclusive	0.51	-0.51	-0.35	0.16	0.30
ukbpd-male-threeptfive Exclusive	OT-PD-Geneburden Exclusive	0.60	-0.11	-0.52	-0.12	1.12
OT-PD-Geneburden Exclusive	Overlap	0.84	0.58	1.09	0.87	1.07
ukbpd-male-threeptfive Exclusive	Overlap	0.45	-1.57	-1.79	-1.11	-0.00
Overlap	Exclusives	0.55	1.14	0.65	0.86	1.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-threeptfive	0.00	-0.63	-0.11	-0.23	-0.03
ukbpd-male-threeptfive Exclusive	OT-PD-Geneburden	0.00	-0.31	-1.00	-0.37	0.22
OT-PD-Geneburden Exclusive	ukbpd-male-threeptfive Exclusive	0.00	-0.59	-0.23	-0.10	-0.11
ukbpd-male-threeptfive Exclusive	OT-PD-Geneburden Exclusive	0.00	-0.17	-0.91	0.01	0.10
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.18	1.67	0.06	-0.11
ukbpd-male-threeptfive Exclusive	Overlap	0.00	-0.67	-0.53	-0.39	-0.24
Overlap	Exclusives	0.00	-0.07	-0.21	-0.04	0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-male-threeptfive Exclusive	70	69	KDM5D
Overlap	1	1