Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-four	1.69e-01	4.81e-01	7.07e-03	8.86e-02
ukbpd-male-four Exclusive	OT-PD-Geneburden	2.23e-01	3.23e-01	8.70e-01	8.88e-01
OT-PD-Geneburden Exclusive	ukbpd-male-four Exclusive	9.65e-02	2.40e-01	6.99e-03	1.81e-01
ukbpd-male-four Exclusive	OT-PD-Geneburden Exclusive	3.07e-01	3.85e-01	8.84e-01	8.03e-01
OT-PD-Geneburden Exclusive	Overlap	5.74e-01	1.98e-02	3.56e-01	3.17e-01
ukbpd-male-four Exclusive	Overlap	1.39e-01	3.76e-01	3.96e-01	9.31e-01
Overlap	Exclusives	2.27e-01	7.96e-01	1.34e-06	6.02e-02



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-male-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-four	0.59	-0.19	0.26	0.38	1.45
ukbpd-male-four Exclusive	OT-PD-Geneburden	0.53	-1.67	-1.65	-1.56	0.32
OT-PD-Geneburden Exclusive	ukbpd-male-four Exclusive	0.58	-0.15	-0.04	0.19	1.35
ukbpd-male-four Exclusive	OT-PD-Geneburden Exclusive	0.54	-1.52	-1.76	-0.90	0.67
OT-PD-Geneburden Exclusive	Overlap	0.84	0.60	1.09	0.88	1.35
ukbpd-male-four Exclusive	Overlap	0.47	-1.32	-1.26	-1.55	-0.16
Overlap	Exclusives	0.60	0.91	0.57	0.92	2.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-four	0.00	-0.49	-0.61	-0.33	-0.03
ukbpd-male-four Exclusive	OT-PD-Geneburden	0.00	-0.36	-0.70	-0.13	0.34
OT-PD-Geneburden Exclusive	ukbpd-male-four Exclusive	0.00	-0.49	-0.74	-0.46	-0.10
ukbpd-male-four Exclusive	OT-PD-Geneburden Exclusive	0.00	-0.30	-0.59	-0.10	1.61
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.24	1.52	-0.07	0.01
ukbpd-male-four Exclusive	Overlap	0.00	-0.64	-0.30	-0.27	-0.33
Overlap	Exclusives	0.00	0.14	-0.36	0.03	0.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-male-four Exclusive	26	25	KDM5D
Overlap	1	1