Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-fourptfive	5.33e-01	8.90e-02	2.79e-03	1.12e-03
ukbpd-male-fourptfive Exclusive	OT-PD-Geneburden	8.77e-01	8.16e-01	2.53e-01	1.58e-01
OT-PD-Geneburden Exclusive	ukbpd-male-fourptfive Exclusive	5.85e-01	9.28e-02	6.29e-03	2.07e-03
ukbpd-male-fourptfive Exclusive	OT-PD-Geneburden Exclusive	6.70e-01	6.56e-01	1.29e-01	8.02e-02
OT-PD-Geneburden Exclusive	Overlap	7.33e-01	1.98e-02	4.55e-01	2.97e-01
ukbpd-male-fourptfive Exclusive	Overlap	2.38e-01	3.76e-01	9.11e-01	7.33e-01
Overlap	Exclusives	9.75e-01	9.84e-01	6.85e-03	1.92e-01



Evaluating how well OT-PD-Geneburden genes are linked to ukbpd-male-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-fourptfive	0.79	1.53	2.35	2.41	3.12
ukbpd-male-fourptfive Exclusive	OT-PD-Geneburden	0.59	-0.12	-0.80	-0.56	1.29
OT-PD-Geneburden Exclusive	ukbpd-male-fourptfive Exclusive	0.78	1.35	1.73	2.18	2.36
ukbpd-male-fourptfive Exclusive	OT-PD-Geneburden Exclusive	0.59	-0.03	-0.87	-0.27	1.29
OT-PD-Geneburden Exclusive	Overlap	0.84	0.56	1.19	0.69	1.18
ukbpd-male-fourptfive Exclusive	Overlap	0.63	-0.97	-0.87	-1.23	0.51
Overlap	Exclusives	0.61	-0.06	-0.14	0.20	1.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OT-PD-Geneburden Exclusive	ukbpd-male-fourptfive	0.00	0.50	1.20	1.41	2.10
ukbpd-male-fourptfive Exclusive	OT-PD-Geneburden	0.00	1.87	1.13	1.73	3.33
OT-PD-Geneburden Exclusive	ukbpd-male-fourptfive Exclusive	0.00	0.71	0.72	1.02	1.71
ukbpd-male-fourptfive Exclusive	OT-PD-Geneburden Exclusive	0.00	2.27	1.47	2.94	5.59
OT-PD-Geneburden Exclusive	Overlap	0.00	-0.17	1.77	-0.10	-0.00
ukbpd-male-fourptfive Exclusive	Overlap	0.00	-0.33	-0.78	-0.32	-0.19
Overlap	Exclusives	0.00	-0.13	-0.31	-0.14	0.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OT-PD-Geneburden Exclusive	12	12	
ukbpd-male-fourptfive Exclusive	7	6	KDM5D
Overlap	1	1