Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PD_cand_eaml_196	sigleton_pd	3.08e-01	1.53e-01	3.69e-01	8.96e-05
sigleton_pd	PD_cand_eaml_196	1.24e-01	9.97e-01	5.51e-10	1.89e-01



Evaluating how well PD_cand_eaml_196 genes are linked to sigleton_pd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_cand_eaml_196	sigleton_pd	0.72	1.04	1.39	0.39	4.02
sigleton_pd	PD_cand_eaml_196	0.46	-0.22	0.16	0.00	-1.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PD_cand_eaml_196	sigleton_pd	0.00	0.43	-0.36	-0.38	1.75
sigleton_pd	PD_cand_eaml_196	0.01	0.16	0.70	-0.06	-0.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PD_cand_eaml_196	196	194	ATG9B;AC010255.3
sigleton_pd	21	21