Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) cand_ad_99_zscore_2_5 new_GS_DL 5.79e-01 1.63e-01 5.10e-01 1.20e-03 new_GS_DL cand_ad_99_zscore_2_5 8.03e-01 5.57e-01 6.94e-08 7.98e-01 Evaluating how well cand_ad_99_zscore_2_5 genes are linked to new_GS_DL genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) cand_ad_99_zscore_2_5 new_GS_DL 0.68 0.12 0.62 -0.33 3.23 new_GS_DL cand_ad_99_zscore_2_5 0.49 1.56 0.48 0.41 -0.32 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) cand_ad_99_zscore_2_5 new_GS_DL 0.00 0.01 1.28 -0.34 3.29 new_GS_DL cand_ad_99_zscore_2_5 0.00 0.04 -0.12 -0.22 -0.72 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes cand_ad_99_zscore_2_5 99 98 AC010616.1 new_GS_DL 22 22