Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top_50_genes_ad_cand	new_GS_DL	7.78e-01	1.11e-01	4.96e-01	4.35e-02
new_GS_DL	top_50_genes_ad_cand	7.37e-01	7.65e-01	9.19e-06	6.36e-01



Evaluating how well top_50_genes_ad_cand genes are linked to new_GS_DL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	new_GS_DL	0.66	0.03	1.36	-0.26	2.49
new_GS_DL	top_50_genes_ad_cand	0.52	2.65	0.81	0.92	0.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	new_GS_DL	0.00	0.05	2.39	-0.16	2.36
new_GS_DL	top_50_genes_ad_cand	0.00	0.89	0.01	0.03	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top_50_genes_ad_cand	50	50	
new_GS_DL	22	22