Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top_50_genes_ad_cand	25_ad_GS	3.21e-01	2.03e-01	4.29e-01	2.90e-03
25_ad_GS	top_50_genes_ad_cand	2.97e-01	5.65e-01	1.61e-01	3.64e-01



Evaluating how well top_50_genes_ad_cand genes are linked to 25_ad_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	25_ad_GS	0.67	0.96	2.19	1.04	2.97
25_ad_GS	top_50_genes_ad_cand	0.55	2.33	1.78	1.73	1.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	25_ad_GS	0.00	-0.01	-0.02	1.27	0.99
25_ad_GS	top_50_genes_ad_cand	0.00	0.23	0.91	1.41	0.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top_50_genes_ad_cand	50	50	
25_ad_GS	25	25