Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cand_ad_99_zscore_2_5	25_ad_GS	4.83e-01	3.86e-01	7.83e-01	3.23e-02
25_ad_GS	cand_ad_99_zscore_2_5	7.70e-01	3.29e-01	1.46e-01	7.72e-01



Evaluating how well cand_ad_99_zscore_2_5 genes are linked to 25_ad_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_ad_99_zscore_2_5	25_ad_GS	0.65	0.63	1.29	0.37	2.50
25_ad_GS	cand_ad_99_zscore_2_5	0.51	2.11	1.18	1.00	0.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cand_ad_99_zscore_2_5	25_ad_GS	0.00	0.14	1.26	0.03	1.99
25_ad_GS	cand_ad_99_zscore_2_5	0.01	1.03	0.47	0.37	-0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cand_ad_99_zscore_2_5	99	98	AC010616.1
25_ad_GS	25	25