Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
pd_Cand_zscore_3_72gene	singleton_21	9.00e-01	5.10e-01	7.60e-01	1.51e-02
singleton_21	pd_Cand_zscore_3_72gene	5.04e-01	9.57e-01	1.07e-04	3.94e-01



Evaluating how well pd_Cand_zscore_3_72gene genes are linked to singleton_21 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
pd_Cand_zscore_3_72gene	singleton_21	0.65	-0.04	0.67	-0.20	2.58
singleton_21	pd_Cand_zscore_3_72gene	0.45	-0.17	0.40	-0.26	-1.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
pd_Cand_zscore_3_72gene	singleton_21	0.00	-0.33	-0.43	-0.54	0.45
singleton_21	pd_Cand_zscore_3_72gene	0.00	-0.10	-0.23	-0.53	-0.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
pd_Cand_zscore_3_72gene	72	72	
singleton_21	21	21