Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
pd_Cand_zscore_3_72gene	Juan_gs	7.13e-01	4.67e-01	6.16e-01	7.00e-03
Juan_gs	pd_Cand_zscore_3_72gene	2.03e-01	8.63e-01	1.28e-07	1.55e-01



Evaluating how well pd_Cand_zscore_3_72gene genes are linked to Juan_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
pd_Cand_zscore_3_72gene	Juan_gs	0.71	0.26	0.58	0.04	2.89
Juan_gs	pd_Cand_zscore_3_72gene	0.45	-0.86	0.54	-0.09	-1.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
pd_Cand_zscore_3_72gene	Juan_gs	0.00	-0.39	-0.69	-0.56	0.42
Juan_gs	pd_Cand_zscore_3_72gene	0.00	-0.25	-0.19	-0.39	-0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
pd_Cand_zscore_3_72gene	72	72	
Juan_gs	12	11	Parkin