Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top_50_genes_ad_cand	new_GS_DL_25	6.33e-01	1.51e-01	6.77e-01	1.92e-02
new_GS_DL_25	top_50_genes_ad_cand	7.69e-01	8.80e-01	3.32e-04	7.60e-01



Evaluating how well top_50_genes_ad_cand genes are linked to new_GS_DL_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	new_GS_DL_25	0.65	-0.15	0.99	-0.05	2.70
new_GS_DL_25	top_50_genes_ad_cand	0.50	1.43	0.42	0.19	0.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	new_GS_DL_25	0.00	0.09	2.06	-0.04	1.07
new_GS_DL_25	top_50_genes_ad_cand	0.00	0.55	-0.03	-0.10	-0.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top_50_genes_ad_cand	50	50	
new_GS_DL_25	25	25