Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top_50_genes_ad_cand	niagads_122_genes	2.82e-01	1.20e-01	2.94e-02	9.04e-01
niagads_122_genes	top_50_genes_ad_cand	1.71e-01	3.28e-01	7.44e-01	7.66e-02



Evaluating how well top_50_genes_ad_cand genes are linked to niagads_122_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	niagads_122_genes	0.49	-1.41	-2.29	-1.73	-0.28
niagads_122_genes	top_50_genes_ad_cand	0.45	-1.17	-0.55	-0.81	-1.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_50_genes_ad_cand	niagads_122_genes	0.01	-1.00	-1.32	-1.07	-0.37
niagads_122_genes	top_50_genes_ad_cand	0.00	-1.12	-0.73	-0.76	-0.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top_50_genes_ad_cand	50	50	
niagads_122_genes	122	121	RFPL2