Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AMP-PD_combinedsex Exclusive	ukbpd-combsex-threeptfive	3.87e-01	2.03e-01	3.81e-01	3.69e-01
ukbpd-combsex-threeptfive Exclusive	AMP-PD_combinedsex	4.37e-01	3.57e-01	5.70e-01	2.63e-01
AMP-PD_combinedsex Exclusive	ukbpd-combsex-threeptfive Exclusive	3.59e-01	9.39e-02	2.23e-01	2.19e-01
ukbpd-combsex-threeptfive Exclusive	AMP-PD_combinedsex Exclusive	4.92e-01	3.25e-01	5.52e-01	4.81e-01
AMP-PD_combinedsex Exclusive	Overlap	1.10e-01	1.93e-01	1.13e-01	3.77e-01
ukbpd-combsex-threeptfive Exclusive	Overlap	7.38e-01	8.29e-01	7.54e-01	5.45e-01
Overlap	Exclusives	7.18e-01	9.49e-01	1.48e-07	8.55e-01



Evaluating how well AMP-PD_combinedsex genes are linked to ukbpd-combsex-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_combinedsex Exclusive	ukbpd-combsex-threeptfive	0.48	-0.94	-1.35	-0.66	-0.64
ukbpd-combsex-threeptfive Exclusive	AMP-PD_combinedsex	0.47	-1.68	-1.44	-1.52	-1.37
AMP-PD_combinedsex Exclusive	ukbpd-combsex-threeptfive Exclusive	0.46	-1.51	-2.17	-1.48	-1.14
ukbpd-combsex-threeptfive Exclusive	AMP-PD_combinedsex Exclusive	0.48	-1.41	-1.21	-1.22	-0.91
AMP-PD_combinedsex Exclusive	Overlap	0.73	2.06	2.12	2.44	1.77
ukbpd-combsex-threeptfive Exclusive	Overlap	0.30	-0.81	-0.97	-0.98	-1.22
Overlap	Exclusives	0.51	0.13	0.04	0.15	0.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_combinedsex Exclusive	ukbpd-combsex-threeptfive	0.00	-0.28	-0.27	-0.31	-0.29
ukbpd-combsex-threeptfive Exclusive	AMP-PD_combinedsex	0.01	-1.78	-1.25	-1.11	-1.13
AMP-PD_combinedsex Exclusive	ukbpd-combsex-threeptfive Exclusive	0.00	-0.91	-0.61	-0.87	-0.34
ukbpd-combsex-threeptfive Exclusive	AMP-PD_combinedsex Exclusive	0.01	-1.70	-1.28	-1.08	-0.84
AMP-PD_combinedsex Exclusive	Overlap	0.00	2.01	0.16	1.44	-0.03
ukbpd-combsex-threeptfive Exclusive	Overlap	0.00	-0.38	-0.19	-0.44	-0.54
Overlap	Exclusives	0.01	0.47	1.11	1.28	1.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AMP-PD_combinedsex Exclusive	155	155	
ukbpd-combsex-threeptfive Exclusive	73	72	KDM5D
Overlap	4	4