Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AMP-PD_female Exclusive	ukbpd-female-threeptfive	4.49e-01	4.00e-01	5.83e-01	3.48e-01
ukbpd-female-threeptfive Exclusive	AMP-PD_female	5.52e-01	9.33e-01	6.49e-01	6.57e-01
AMP-PD_female Exclusive	ukbpd-female-threeptfive Exclusive	7.87e-01	4.97e-01	8.29e-01	7.56e-01
ukbpd-female-threeptfive Exclusive	AMP-PD_female Exclusive	6.20e-01	8.83e-01	7.57e-01	6.69e-01
AMP-PD_female Exclusive	Overlap	2.48e-01	1.45e-01	3.26e-01	6.22e-02
ukbpd-female-threeptfive Exclusive	Overlap	7.40e-01	8.36e-01	6.40e-01	5.39e-01
Overlap	Exclusives	5.07e-02	6.11e-01	5.39e-13	9.23e-01



Evaluating how well AMP-PD_female genes are linked to ukbpd-female-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_female Exclusive	ukbpd-female-threeptfive	0.47	-1.09	-0.75	-1.29	-0.97
ukbpd-female-threeptfive Exclusive	AMP-PD_female	0.50	0.35	0.10	0.13	0.23
AMP-PD_female Exclusive	ukbpd-female-threeptfive Exclusive	0.48	-0.62	-0.54	-0.86	-0.28
ukbpd-female-threeptfive Exclusive	AMP-PD_female Exclusive	0.51	0.33	0.32	-0.06	0.07
AMP-PD_female Exclusive	Overlap	0.13	-1.45	-1.77	-1.57	-2.38
ukbpd-female-threeptfive Exclusive	Overlap	0.40	0.04	-0.00	0.25	-0.66
Overlap	Exclusives	0.50	-0.74	-0.78	-0.29	-0.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_female Exclusive	ukbpd-female-threeptfive	0.00	-0.25	1.00	-0.57	0.05
ukbpd-female-threeptfive Exclusive	AMP-PD_female	0.01	-0.33	-0.30	-0.41	-0.30
AMP-PD_female Exclusive	ukbpd-female-threeptfive Exclusive	0.00	-0.18	0.98	-0.26	0.05
ukbpd-female-threeptfive Exclusive	AMP-PD_female Exclusive	0.01	-0.22	-0.12	-0.54	-0.31
AMP-PD_female Exclusive	Overlap	0.00	-0.20	-0.90	-0.43	-0.62
ukbpd-female-threeptfive Exclusive	Overlap	0.00	-0.31	-0.46	-0.13	-0.25
Overlap	Exclusives	0.01	-0.72	-0.56	-0.52	-0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AMP-PD_female Exclusive	113	113	
ukbpd-female-threeptfive Exclusive	67	67	
Overlap	3	3