Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AMP-PD_female Exclusive	ukbpd-female-fourptfive	2.85e-01	3.37e-01	4.38e-01	7.79e-01
ukbpd-female-fourptfive Exclusive	AMP-PD_female	6.35e-01	4.99e-01	1.10e-01	5.76e-01
AMP-PD_female Exclusive	ukbpd-female-fourptfive Exclusive	3.14e-01	4.87e-01	4.92e-01	8.88e-01
ukbpd-female-fourptfive Exclusive	AMP-PD_female Exclusive	6.71e-01	4.92e-01	1.70e-01	6.74e-01
AMP-PD_female Exclusive	Overlap	5.54e-01	2.18e-01	5.74e-01	1.58e-01
ukbpd-female-fourptfive Exclusive	Overlap	3.96e-02	2.77e-01	1.98e-01	6.93e-01
Overlap	Exclusives	9.39e-01	7.13e-01	3.59e-08	2.99e-01



Evaluating how well AMP-PD_female genes are linked to ukbpd-female-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_female Exclusive	ukbpd-female-fourptfive	0.45	-2.13	-1.47	-1.81	-0.65
ukbpd-female-fourptfive Exclusive	AMP-PD_female	0.48	-0.54	-0.83	-0.68	-0.60
AMP-PD_female Exclusive	ukbpd-female-fourptfive Exclusive	0.48	-1.85	-1.14	-1.47	-0.38
ukbpd-female-fourptfive Exclusive	AMP-PD_female Exclusive	0.48	-0.61	-0.86	-0.60	-0.50
AMP-PD_female Exclusive	Overlap	0.05	-0.82	-1.06	-0.86	-1.63
ukbpd-female-fourptfive Exclusive	Overlap	0.42	2.85	0.82	0.95	-0.46
Overlap	Exclusives	0.52	0.42	0.34	0.90	0.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_female Exclusive	ukbpd-female-fourptfive	0.00	-0.92	-0.04	-0.39	-0.25
ukbpd-female-fourptfive Exclusive	AMP-PD_female	0.01	-0.57	-0.52	-1.07	-0.92
AMP-PD_female Exclusive	ukbpd-female-fourptfive Exclusive	0.00	-0.19	0.06	-0.79	-0.20
ukbpd-female-fourptfive Exclusive	AMP-PD_female Exclusive	0.01	-0.69	-0.59	-0.83	-0.54
AMP-PD_female Exclusive	Overlap	0.00	-0.30	-0.56	-0.38	-0.12
ukbpd-female-fourptfive Exclusive	Overlap	0.00	-0.01	-0.14	-0.15	-0.15
Overlap	Exclusives	0.01	0.10	0.71	0.71	0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AMP-PD_female Exclusive	115	115	
ukbpd-female-fourptfive Exclusive	18	18	
Overlap	1	1