Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AMP-PD_male	ukbpd-male-fourptfive	3.70e-01	3.67e-02	6.83e-01	8.44e-01
ukbpd-male-fourptfive	AMP-PD_male	2.80e-01	8.41e-01	7.09e-07	2.57e-01



Evaluating how well AMP-PD_male genes are linked to ukbpd-male-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_male	ukbpd-male-fourptfive	0.48	-1.78	-2.62	-1.88	-0.15
ukbpd-male-fourptfive	AMP-PD_male	0.52	-1.88	-0.80	-0.76	0.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_male	ukbpd-male-fourptfive	0.00	-0.82	-0.66	-1.25	-0.48
ukbpd-male-fourptfive	AMP-PD_male	0.01	-1.39	-1.34	-0.72	-0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AMP-PD_male	120	120	
ukbpd-male-fourptfive	8	7	KDM5D