Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cohort	erikson	6.97e-02	6.40e-01	2.32e-01	5.19e-01
erikson	cohort	1.25e-02	5.75e-03	1.18e-02	5.69e-03



Evaluating how well cohort genes are linked to erikson genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort	erikson	0.54	0.86	1.09	1.06	1.30
erikson	cohort	0.62	1.39	3.25	1.32	2.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort	erikson	0.00	1.11	1.20	1.03	0.14
erikson	cohort	0.00	0.31	2.35	0.38	2.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cohort	55	54	MUC19
erikson	50	50