Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cohort	25_ad_gwas	4.14e-01	9.80e-02	4.81e-01	3.81e-04
25_ad_gwas	cohort	5.40e-01	3.62e-03	1.11e-05	4.72e-04



Evaluating how well cohort genes are linked to 25_ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort	25_ad_gwas	0.71	1.71	2.58	1.77	3.58
25_ad_gwas	cohort	0.63	1.84	3.48	1.25	3.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort	25_ad_gwas	0.00	1.04	1.55	0.82	2.19
25_ad_gwas	cohort	0.00	0.52	1.53	0.03	0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cohort	55	54	MUC19
25_ad_gwas	25	24	HLA -DRB1