Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cohort Exclusive	bailey_pancan	1.33e-09	3.25e-01	6.89e-12	5.04e-18
bailey_pancan Exclusive	cohort	4.36e-03	7.91e-02	4.72e-04	4.29e-01
cohort Exclusive	bailey_pancan Exclusive	9.31e-11	3.56e-01	8.07e-12	2.66e-17
bailey_pancan Exclusive	cohort Exclusive	5.33e-03	5.91e-02	6.05e-04	2.42e-01
cohort Exclusive	Overlap	8.91e-01	1.98e-02	7.92e-01	1.98e-01
bailey_pancan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.70e-25	1.07e-20	1.07e-94	2.86e-73



Evaluating how well cohort genes are linked to bailey_pancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort Exclusive	bailey_pancan	0.69	-0.03	1.28	-0.56	8.22
bailey_pancan Exclusive	cohort	0.50	0.63	-0.44	-0.60	0.01
cohort Exclusive	bailey_pancan Exclusive	0.68	-0.31	1.14	-0.63	8.70
bailey_pancan Exclusive	cohort Exclusive	0.49	0.68	-0.74	-0.53	-0.33
cohort Exclusive	Overlap	0.87	0.32	2.12	0.45	1.53
bailey_pancan Exclusive	Overlap	1.00	1.49	1.13	1.13	1.51
Overlap	Exclusives	0.80	3.43	7.58	1.92	16.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort Exclusive	bailey_pancan	0.02	-0.06	1.63	-0.46	5.37
bailey_pancan Exclusive	cohort	0.00	5.46	7.08	0.40	0.83
cohort Exclusive	bailey_pancan Exclusive	0.02	-0.22	1.42	-0.55	4.99
bailey_pancan Exclusive	cohort Exclusive	0.00	1.30	0.39	-0.40	-0.18
cohort Exclusive	Overlap	0.00	-0.30	3.77	-0.23	0.48
bailey_pancan Exclusive	Overlap	0.10	14.58	115.13	111.17	177.93
Overlap	Exclusives	0.05	4.87	17.48	2.45	48.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cohort Exclusive	54	53	MUC19
bailey_pancan Exclusive	199	199	
Overlap	1	1