Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cohort	tier1	1.91e-01	1.41e-03	1.69e-01	1.92e-06
tier1	cohort	9.10e-01	1.81e-02	9.18e-04	1.58e-03



Evaluating how well cohort genes are linked to tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort	tier1	0.71	2.07	3.47	1.99	4.37
tier1	cohort	0.61	1.26	2.71	1.34	3.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cohort	tier1	0.00	0.49	1.30	0.71	1.34
tier1	cohort	0.00	-0.07	1.38	0.06	0.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cohort	55	54	MUC19
tier1	31	30	MS4A