Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2meth0d_3ea_87 Exclusive	TIER1_GS	5.57e-15	1.27e-14	3.15e-15	1.91e-15
TIER1_GS Exclusive	2meth0d_3ea_87	9.62e-03	9.34e-03	8.97e-04	3.74e-04
2meth0d_3ea_87 Exclusive	TIER1_GS Exclusive	1.24e-12	2.32e-13	1.09e-13	8.37e-13
TIER1_GS Exclusive	2meth0d_3ea_87 Exclusive	4.25e-02	1.15e-02	1.91e-03	1.18e-03
2meth0d_3ea_87 Exclusive	Overlap	4.36e-07	4.36e-07	1.74e-06	1.74e-06
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.06e-06	8.89e-08	1.67e-20	4.33e-09



Evaluating how well 2meth0d_3ea_87 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2meth0d_3ea_87 Exclusive	TIER1_GS	0.90	5.16	7.92	4.55	7.82
TIER1_GS Exclusive	2meth0d_3ea_87	0.60	2.94	2.77	3.48	3.40
2meth0d_3ea_87 Exclusive	TIER1_GS Exclusive	0.89	4.55	7.98	4.56	7.05
TIER1_GS Exclusive	2meth0d_3ea_87 Exclusive	0.59	2.87	2.58	2.87	2.81
2meth0d_3ea_87 Exclusive	Overlap	1.00	2.34	2.75	2.77	2.98
TIER1_GS Exclusive	Overlap	1.00	2.86	2.91	2.78	3.06
Overlap	Exclusives	0.68	3.75	8.00	3.30	7.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2meth0d_3ea_87 Exclusive	TIER1_GS	0.08	133.23	191.22	93.79	22.58
TIER1_GS Exclusive	2meth0d_3ea_87	0.05	45.40	69.80	83.19	82.82
2meth0d_3ea_87 Exclusive	TIER1_GS Exclusive	0.06	86.92	113.58	98.50	14.87
TIER1_GS Exclusive	2meth0d_3ea_87 Exclusive	0.03	48.80	50.11	20.12	50.30
2meth0d_3ea_87 Exclusive	Overlap	0.03	43.14	132.98	82.34	74.86
TIER1_GS Exclusive	Overlap	0.10	170.78	124.37	402.88	237.24
Overlap	Exclusives	0.12	56.05	213.00	33.23	189.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2meth0d_3ea_87 Exclusive	84	82	AL162417.1;RFPL2
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3