Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1 Exclusive	TIER1_GS	1.45e-15	1.70e-14	1.57e-15	1.91e-15
TIER1_GS Exclusive	GeneGroup1	2.42e-02	4.35e-02	8.66e-03	6.57e-03
GeneGroup1 Exclusive	TIER1_GS Exclusive	6.74e-13	1.09e-13	6.50e-13	7.79e-13
TIER1_GS Exclusive	GeneGroup1 Exclusive	5.89e-02	8.95e-02	2.72e-02	2.68e-02
GeneGroup1 Exclusive	Overlap	4.36e-07	1.74e-06	4.36e-07	1.74e-06
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.09e-07	1.31e-07	3.51e-23	5.95e-09



Evaluating how well GeneGroup1 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	TIER1_GS	0.88	4.49	7.48	4.16	7.60
TIER1_GS Exclusive	GeneGroup1	0.57	3.34	3.00	2.23	2.42
GeneGroup1 Exclusive	TIER1_GS Exclusive	0.87	4.60	8.33	4.48	7.58
TIER1_GS Exclusive	GeneGroup1 Exclusive	0.56	3.66	2.03	2.08	1.78
GeneGroup1 Exclusive	Overlap	1.00	2.28	2.60	2.70	2.89
TIER1_GS Exclusive	Overlap	1.00	2.74	2.43	3.20	2.96
Overlap	Exclusives	0.67	3.59	7.18	3.68	6.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	TIER1_GS	0.04	61.43	113.26	12.25	59.35
TIER1_GS Exclusive	GeneGroup1	0.04	49.22	81.60	19.69	67.11
GeneGroup1 Exclusive	TIER1_GS Exclusive	0.03	30.24	98.10	33.55	54.61
TIER1_GS Exclusive	GeneGroup1 Exclusive	0.03	51.82	46.70	20.15	39.11
GeneGroup1 Exclusive	Overlap	0.03	31.73	50.84	68.01	68.52
TIER1_GS Exclusive	Overlap	0.10	205.10	106.90	339.41	478.86
Overlap	Exclusives	0.11	43.90	180.77	101.96	181.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1 Exclusive	89	87	RFPL2;AL162417.1
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3