Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	geneAgeAll	4.47e-06	7.27e-07	9.51e-04	6.54e-37
geneAgeAll	aging	6.34e-02	3.18e-01	1.01e-06	4.62e-01



Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.74	0.43	6.71	0.86	13.05
geneAgeAll	aging	0.52	2.43	0.17	-0.32	0.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.03	-0.53	7.46	0.03	13.79
geneAgeAll	aging	0.01	3.42	0.31	-0.24	0.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	104	103	MUC19
geneAgeAll	307	306	TERC