Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	ad_gwas	2.28e-01	2.87e-02	8.91e-02	3.84e-03
ad_gwas	aging	6.72e-01	2.34e-01	2.82e-02	1.85e-01



Evaluating how well aging genes are linked to ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.69	0.82	2.27	1.20	3.21
ad_gwas	aging	0.55	0.65	1.05	0.53	1.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.00	0.17	1.95	0.99	1.80
ad_gwas	aging	0.01	0.39	0.36	0.06	0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	104	103	MUC19
ad_gwas	25	25