Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) aging geneAgeAll 1.19e-01 5.81e-12 2.59e-01 3.34e-64 geneAgeAll aging 1.99e-01 1.83e-01 2.11e-03 3.11e-01 Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) aging geneAgeAll 0.78 3.21 9.57 2.04 16.62 geneAgeAll aging 0.47 2.20 -0.89 -0.62 -0.62 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) aging geneAgeAll 0.04 3.18 11.44 1.28 14.89 geneAgeAll aging 0.00 8.99 2.73 0.11 1.17 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes aging 43 43 geneAgeAll 307 306 TERC