Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	geneAgeAll	1.19e-01	5.81e-12	2.59e-01	3.34e-64
geneAgeAll	aging	1.99e-01	1.83e-01	2.11e-03	3.11e-01



Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.78	3.21	9.57	2.04	16.62
geneAgeAll	aging	0.47	2.20	-0.89	-0.62	-0.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	geneAgeAll	0.04	3.18	11.44	1.28	14.89
geneAgeAll	aging	0.00	8.99	2.73	0.11	1.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	43	43	
geneAgeAll	307	306	TERC