Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	ad_gwas	7.79e-01	8.59e-01	4.86e-01	3.39e-02
ad_gwas	aging	8.53e-01	2.99e-01	3.51e-01	6.22e-01



Evaluating how well aging genes are linked to ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.64	0.57	0.87	0.30	2.57
ad_gwas	aging	0.51	0.67	0.34	0.22	0.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.00	-0.09	0.26	-0.21	0.19
ad_gwas	aging	0.00	-0.06	-0.19	-0.29	-0.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	43	43	
ad_gwas	25	25