Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	tier1_ad	9.44e-01	1.08e-01	9.34e-01	9.43e-03
tier1_ad	aging	4.59e-01	2.91e-01	7.69e-01	6.63e-01



Evaluating how well aging genes are linked to tier1_ad genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.66	1.18	1.80	1.11	2.99
tier1_ad	aging	0.52	0.51	0.31	0.02	0.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.00	0.07	0.95	0.64	1.55
tier1_ad	aging	0.00	-0.11	-0.07	-0.27	-0.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	45	45	
tier1_ad	31	30	MS4A