Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	ad_gwas	9.45e-01	3.57e-01	9.38e-01	1.53e-02
ad_gwas	aging	6.95e-01	3.58e-01	2.41e-01	4.73e-01



Evaluating how well aging genes are linked to ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.66	0.95	1.58	0.74	3.34
ad_gwas	aging	0.53	0.80	0.44	0.38	0.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.00	0.08	1.25	0.18	0.41
ad_gwas	aging	0.00	0.21	-0.12	-0.15	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	45	45	
ad_gwas	25	25