Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	bailey_pancan	1.78e-05	1.31e-01	6.70e-03	1.09e-26
bailey_pancan	aging	2.14e-02	6.55e-01	3.53e-07	1.85e-01



Evaluating how well aging genes are linked to bailey_pancan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	bailey_pancan	0.72	-0.83	2.47	0.27	11.41
bailey_pancan	aging	0.57	0.62	0.61	0.14	2.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	bailey_pancan	0.02	-0.99	2.05	-0.12	8.72
bailey_pancan	aging	0.00	0.19	-0.38	-0.02	1.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	76	75	MUC19
bailey_pancan	200	200