Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	tier1_ad	2.77e-01	4.75e-02	1.79e-01	2.38e-03
tier1_ad	aging	7.09e-01	7.53e-02	2.76e-02	1.16e-03



Evaluating how well aging genes are linked to tier1_ad genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.68	1.39	2.55	1.34	3.52
tier1_ad	aging	0.62	1.09	2.64	1.17	3.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.00	0.64	0.76	0.57	1.06
tier1_ad	aging	0.01	0.29	0.23	0.13	0.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	76	75	MUC19
tier1_ad	31	30	MS4A