Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	ad_gwas	1.37e-01	2.29e-02	9.96e-03	1.24e-03
ad_gwas	aging	3.88e-01	3.14e-02	2.49e-03	7.41e-04



Evaluating how well aging genes are linked to ad_gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.72	1.14	2.94	1.59	3.63
ad_gwas	aging	0.64	1.74	3.28	1.75	3.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	ad_gwas	0.00	0.35	2.32	1.38	1.15
ad_gwas	aging	0.01	1.56	0.44	0.64	2.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	76	75	MUC19
ad_gwas	25	25