Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging Exclusive	geneAgeAll	3.68e-04	1.41e-12	4.01e-05	1.00e-39
geneAgeAll Exclusive	aging	8.82e-02	1.79e-01	1.49e-05	5.31e-01
aging Exclusive	geneAgeAll Exclusive	4.37e-04	2.52e-12	2.05e-04	3.09e-40
geneAgeAll Exclusive	aging Exclusive	7.82e-02	1.77e-01	1.34e-05	7.82e-01
aging Exclusive	Overlap	9.70e-01	1.98e-02	8.91e-01	2.97e-01
geneAgeAll Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.79e-35	2.20e-22	6.21e-129	2.13e-86



Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging Exclusive	geneAgeAll	0.73	1.36	6.66	0.83	13.44
geneAgeAll Exclusive	aging	0.53	3.69	0.96	0.10	0.90
aging Exclusive	geneAgeAll Exclusive	0.73	1.34	6.84	0.94	15.08
geneAgeAll Exclusive	aging Exclusive	0.53	2.85	0.99	0.21	0.58
aging Exclusive	Overlap	0.86	0.13	9.68	0.34	1.30
geneAgeAll Exclusive	Overlap	1.00	2.46	0.92	0.90	1.77
Overlap	Exclusives	0.80	1.59	8.79	2.14	20.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging Exclusive	geneAgeAll	0.03	0.83	7.21	0.24	13.05
geneAgeAll Exclusive	aging	0.02	66.16	51.43	6.82	33.06
aging Exclusive	geneAgeAll Exclusive	0.03	0.76	7.14	0.34	12.88
geneAgeAll Exclusive	aging Exclusive	0.00	3.50	1.43	0.01	0.11
aging Exclusive	Overlap	0.00	-0.33	31.96	-0.24	0.69
geneAgeAll Exclusive	Overlap	1.00	212.80	346.56	810.62	462.97
Overlap	Exclusives	0.08	2.60	25.55	3.95	51.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging Exclusive	59	58	MUC19
geneAgeAll Exclusive	306	305	TERC
Overlap	1	1