Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) aging Exclusive geneAgeAll 3.68e-04 1.41e-12 4.01e-05 1.00e-39 geneAgeAll Exclusive aging 8.82e-02 1.79e-01 1.49e-05 5.31e-01 aging Exclusive geneAgeAll Exclusive 4.37e-04 2.52e-12 2.05e-04 3.09e-40 geneAgeAll Exclusive aging Exclusive 7.82e-02 1.77e-01 1.34e-05 7.82e-01 aging Exclusive Overlap 9.70e-01 1.98e-02 8.91e-01 2.97e-01 geneAgeAll Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 3.79e-35 2.20e-22 6.21e-129 2.13e-86 Evaluating how well aging genes are linked to geneAgeAll genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) aging Exclusive geneAgeAll 0.73 1.36 6.66 0.83 13.44 geneAgeAll Exclusive aging 0.53 3.69 0.96 0.10 0.90 aging Exclusive geneAgeAll Exclusive 0.73 1.34 6.84 0.94 15.08 geneAgeAll Exclusive aging Exclusive 0.53 2.85 0.99 0.21 0.58 aging Exclusive Overlap 0.86 0.13 9.68 0.34 1.30 geneAgeAll Exclusive Overlap 1.00 2.46 0.92 0.90 1.77 Overlap Exclusives 0.80 1.59 8.79 2.14 20.61 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) aging Exclusive geneAgeAll 0.03 0.83 7.21 0.24 13.05 geneAgeAll Exclusive aging 0.02 66.16 51.43 6.82 33.06 aging Exclusive geneAgeAll Exclusive 0.03 0.76 7.14 0.34 12.88 geneAgeAll Exclusive aging Exclusive 0.00 3.50 1.43 0.01 0.11 aging Exclusive Overlap 0.00 -0.33 31.96 -0.24 0.69 geneAgeAll Exclusive Overlap 1.00 212.80 346.56 810.62 462.97 Overlap Exclusives 0.08 2.60 25.55 3.95 51.03 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes aging Exclusive 59 58 MUC19 geneAgeAll Exclusive 306 305 TERC Overlap 1 1