Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
aging	tier1_ad	2.69e-01	2.04e-03	2.77e-01	4.34e-06
tier1_ad	aging	9.56e-01	4.55e-03	4.60e-04	9.56e-04



Evaluating how well aging genes are linked to tier1_ad genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.71	2.59	3.53	1.79	4.06
tier1_ad	aging	0.61	1.01	3.99	1.19	3.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
aging	tier1_ad	0.00	1.81	1.53	0.67	2.81
tier1_ad	aging	0.00	-0.11	1.59	-0.01	0.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
aging	60	59	MUC19
tier1_ad	31	30	MS4A